PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2

Ibuprofen, in addition to having beneficial properties, cause serious side effects, ranging from gastrointestinal ulcerations until bleeding. These unwanted effects stimulate the research & development of new and more effective therapeutic agents and less harmful to human health. In this context, the aim of this study was to conduct an in silico study to evaluate pharmacokinetics properties, toxic effects and interaction of ibuprofenates derived from natural products with prostaglandin G/H synthase 2. The anisyl, thymil and eugenyl ibuprofenates showed molecular properties and low or no toxicity, expected for bioactive substances with potential drug candidates. Furthermore, it was observed that the ibuprofenates evaluated had higher interaction energy with the prostaglandin G/H synthase 2 in a similar orientation to ibuprofen drug.