Cost-effectiveness of pre-exposure prophylaxis (PrEP) in preventing HIV-1 infections in rural Zambia: a modeling study.

Authors :: Brooke E Nichols
Charles A B Boucher
Janneke H van Dijk
Phil E Thuma
Jan L Nouwen
Rob Baltussen
Janneke van de Wijgert
Peter M A Sloot
David A M C van de Vijver
Source :: PLoS ONE, Vol 8, Iss 3, p e59549 (2013)
Publication Year :: 2013
Publisher :: Public Library of Science (PLoS), 2013.
Abstract: BACKGROUND: Pre-exposure prophylaxis (PrEP) with tenofovir and emtricitabine effectively prevents new HIV infections. The optimal scenario for implementing PrEP where most infections are averted at the lowest cost is unknown. We determined the impact of different PrEP strategies on averting new infections, prevalence, drug resistance and cost-effectiveness in Macha, a rural setting in Zambia. METHODS: A deterministic mathematical model of HIV transmission was constructed using data from the Macha epidemic (antenatal prevalence 7.7%). Antiretroviral therapy is started at CD4

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