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A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway

Authors :
Bhav Harshad Parikh
Zengping Liu
Paul Blakeley
Qianyu Lin
Malay Singh
Jun Yi Ong
Kim Han Ho
Joel Weijia Lai
Hanumakumar Bogireddi
Kim Chi Tran
Jason Y. C. Lim
Kun Xue
Abdurrahmaan Al-Mubaarak
Binxia Yang
Sowmiya R
Kakkad Regha
Daniel Soo Lin Wong
Queenie Shu Woon Tan
Zhongxing Zhang
Anand D. Jeyasekharan
Veluchamy Amutha Barathi
Weimiao Yu
Kang Hao Cheong
Timothy A. Blenkinsop
Walter Hunziker
Gopal Lingam
Xian Jun Loh
Xinyi Su
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

One common cause of vision loss after retinal detachment surgery is retinal scarring. Here the authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppression of epithelial-mesenchymal transition and hyper-proliferation of retinal pigment epithelial cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.29658a3e9704480d80f0623a65432050
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-30474-6