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Natural Products from Marine-Derived Fungi with Anti-Inflammatory Activity

Authors :
Yikang Qiu
Shiji Chen
Miao Yu
Jueying Shi
Jiayu Liu
Xiaoyang Li
Jiaxing Chen
Xueping Sun
Guolei Huang
Caijuan Zheng
Source :
Marine Drugs, Vol 22, Iss 10, p 433 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Inflammation is considered as one of the most primary protective innate immunity responses, closely related to the body’s defense mechanism for responding to chemical, biological infections, or physical injuries. Furthermore, prolonged inflammation is undesirable, playing an important role in the development of various diseases, such as heart disease, diabetes, Alzheimer’s disease, atherosclerosis, rheumatoid arthritis, and even certain cancers. Marine-derived fungi represent promising sources of structurally novel bioactive natural products, and have been a focus of research for the development of anti-inflammatory drugs. This review covers secondary metabolites with anti-inflammatory activities from marine-derived fungi, over the period spanning August 2018 to July 2024. A total of 285 anti-inflammatory metabolites, including 156 novel compounds and 11 with novel skeleton structures, are described. Their structures are categorized into five categories: terpenoids, polyketides, nitrogen-containing compounds, steroids, and other classes. The biological targets, as well as the in vitro and in vivo screening models, were surveyed and statistically summarized. This paper aims to offer valuable insights to researchers in the exploration of natural products and the discovery of anti-inflammatory drugs.

Details

Language :
English
ISSN :
16603397
Volume :
22
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.294ab3204fa432a810b515c8f8d2d63
Document Type :
article
Full Text :
https://doi.org/10.3390/md22100433