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Peptide-Templated Gold Clusters as Enzyme-Like Catalyst Boost Intracellular Oxidative Pressure and Induce Tumor-Specific Cell Apoptosis

Authors :
Ya Zhang
Xiangchun Zhang
Qing Yuan
Wenchao Niu
Chunyu Zhang
Jiaojiao Li
Zhesheng He
Yuhua Tang
Xiaojun Ren
Zhichao Zhang
Pengju Cai
Liang Gao
Xueyun Gao
Source :
Nanomaterials, Vol 8, Iss 12, p 1040 (2018)
Publication Year :
2018
Publisher :
MDPI AG, 2018.

Abstract

Anticancer metallodrugs that aim to physiological characters unique to tumor microenvironment are expected to combat drug tolerance and side-effects. Recently, owing to the fact that reactive oxygen species’ is closely related to the development of tumors, people are committed to developing metallodrugs with the capacity of improving the level of reactive oxygen species level toinduce oxidative stress in cancer cells. Herein, we demonstrated that peptide templated gold clusters with atomic precision preferably catalyze the transformation of hydrogen peroxide into superoxide anion in oxidative pressure-type tumor cells. Firstly, we successfully constructed gold clusters by rationally designing peptide sequences which targets integrin ανβ3 overexpressed on glioblastoma cells. The superoxide anion, radical derived from hydrogen peroxide and catalyzed by gold clusters, was confirmed in vitro under pseudo-physiological conditions. Then, kinetic parameters were evaluated to verify the catalytic properties of gold clusters. Furthermore, these peptide decorated clusters can serve as special enzyme-like catalyst to convert endogenous hydrogen peroxide into superoxide anion, elevated intracellular reactive oxygen species levels, lower mitochondrial membrane potential, damage biomacromolecules, and trigger tumor cell apoptosis consequently.

Details

Language :
English
ISSN :
20794991
Volume :
8
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Nanomaterials
Publication Type :
Academic Journal
Accession number :
edsdoj.29446f728cb7415591f34478998b7ee9
Document Type :
article
Full Text :
https://doi.org/10.3390/nano8121040