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Focused ultrasound-induced cell apoptosis for the treatment of tumours

Authors :
Na Wang
Li Luo
Xinzhi Xu
Hang Zhou
Fang Li
Source :
PeerJ, Vol 12, p e17886 (2024)
Publication Year :
2024
Publisher :
PeerJ Inc., 2024.

Abstract

Cancer is a serious public health problem worldwide. Traditional treatments, such as surgery, radiotherapy, chemotherapy, and immunotherapy, do not always yield satisfactory results; therefore, an efficient treatment for tumours is urgently needed. As a convenient and minimally invasive modality, focused ultrasound (FUS) has been used not only as a diagnostic tool but also as a therapeutic tool in an increasing number of studies. FUS can help treat malignant tumours by inducing apoptosis. This review describes the three apoptotic pathways, apoptotic cell clearance, and how FUS affects these three apoptotic pathways. This review also discusses the role of thermal and cavitation effects on apoptosis, including caspase activity, mitochondrial dysfunction, and Ca2+ elease. Finally, this article reviews various aspects of FUS combination therapy, including sensitization by radiotherapy and chemotherapy, gene expression upregulation, and the introduction of therapeutic gases, to provide new ideas for clinical tumour therapy.

Details

Language :
English
ISSN :
21678359
Volume :
12
Database :
Directory of Open Access Journals
Journal :
PeerJ
Publication Type :
Academic Journal
Accession number :
edsdoj.291519b342194525b6b8af9a8bd27f6f
Document Type :
article
Full Text :
https://doi.org/10.7717/peerj.17886