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ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis

Authors :
Christophe Royer
Elizabeth Sandham
Elizabeth Slee
Falk Schneider
Christoffer B. Lagerholm
Jonathan Godwin
Nisha Veits
Holly Hathrell
Felix Zhou
Karolis Leonavicius
Jemma Garratt
Tanaya Narendra
Anna Vincent
Celine Jones
Tim Child
Kevin Coward
Chris Graham
Marco Fritzsche
Xin Lu
Shankar Srinivas
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The early embryo maintains its structure in the face of large mechanical stresses during morphogenesis. Here they show that ASPP2 acts to preserve epithelial integrity in regions of high apical tension during early development.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.28cde804539b4aaba4e1341177ac28d1
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-28590-4