Back to Search Start Over

Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia

Authors :
Xie Lin
Ding Ning
Sheng Siqi
Zhang Honghong
Yin He
Gao Lina
Zhang Hui
Ma Shengchao
Yang Anning
Li Guizhong
Jiao Yun
Shi Qing
Jiang Yideng
Zhang Huiping
Source :
Acta Biochimica et Biophysica Sinica, Vol 55, Pp 202-214 (2023)
Publication Year :
2023
Publisher :
China Science Publishing & Media Ltd., 2023.

Abstract

Accumulating evidence has shown that the apoptosis of trophoblast cells plays an important role in the pathogenesis of preeclampsia, and an intricate interplay between DNA methylation and polycomb group (PcG) protein-mediated gene silencing has been highlighted recently. Here, we provide evidence that the expression of nervous system polycomb 1 (NSPc1), a BMI1 homologous polycomb protein, is significantly elevated in trophoblast cells during preeclampsia, which accelerates trophoblast cell apoptosis. Since NSPc1 acts predominantly as a transcriptional inactivator that specifically represses HOXA11 expression in trophoblast cells during preeclampsia, we further show that NSPc1 is required for DNMT3a recruitment and maintenance of the DNA methylation in the HOXA11 promoter in trophoblast cells during preeclampsia. In addition, we find that the interplay of DNMT3a and NSPc1 represses the expression of HOXA11 and promotes trophoblast cell apoptosis. Taken together, these results indicate that the cooperation between NSPc1 and DNMT3a reduces HOXA11 expression in preeclampsia pathophysiology, which provides novel therapeutic approaches for targeted inhibition of trophoblast cell apoptosis during preeclampsia pathogenesis.

Details

Language :
English
ISSN :
16729145
Volume :
55
Database :
Directory of Open Access Journals
Journal :
Acta Biochimica et Biophysica Sinica
Publication Type :
Academic Journal
Accession number :
edsdoj.28b8779b2b24360a5b6c1fe2fa221d3
Document Type :
article
Full Text :
https://doi.org/10.3724/abbs.2023012