External validation of the prognostic relevance of the advanced lung cancer inflammation index (ALI) in pancreatic cancer patients

Abstract Background The advanced lung cancer inflammation index (ALI) was first introduced for prognosis prediction in lung cancer patients and since then evaluated in several other malignancies. However, in pancreatic cancer (PC) the ALI and its prognostic utility were only investigated in a comparably small and specific cohort of locally advanced PC patients treated with chemoradiotherapy. Methods In our single‐center cohort study, we included 429 patients with histologically verified PC who were treated between 2003 and 2015 at our academic institution. The ALI was defined as body mass index (BMI; kg/m2) × serum albumin levels (g/dL)/neutrophil‐lymphocyte ratio (NLR) and we defined the optimal cutoff for biomarker dichotomization by ROC‐analysis. Kaplan‐Meier method as well as uni‐ and multivariate Cox regression Hazard proportional models were implemented to assess the prognostic potential of ALI in PC patients. We considered cancer‐specific survival (CSS) as the primary endpoint of the study. Results The ALI showed a significant negative correlation with CA19‐9 levels and C‐reactive protein levels whereas we found an association with localized tumor stage and better performance status (P