Oxidant/antioxidant balance in patients with thyroid cancer

Authors :: Melih Akinci
Funda Kosova
Bahadir Çetin
Aylin Sepici
Nilgün Altan
Sebahattin Aslan
Abdullah Çetin
Source :: Acta Cirúrgica Brasileira, Vol 23, Iss 6, Pp 551-554 (2008)
Publication Year :: 2008
Publisher :: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2008.
Abstract: PURPOSE: To compare the antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the levels of lipid peroxidation product malondialdehyde (MDA) in blood samples of thyroid cancer patients compared to healthy controls. METHODS: 43 control subjects (mean age 44±13 years) and 43 patients (43±13 years) presented with multinodular goiter whose fine needle aspiration revealed malignant cytology were included into this study. The SOD, MDA and GSH-Px activities were measured in control subjects, and before/20 days after thyroidectomy in thyroid cancer patients. RESULTS: SOD activities of pre-thyroidectomy, post-thyroidectomy and control groups were not different (p>0.05). Before thyroidectomy GSH-Px activities were lower (p