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Liver markers, prevalence of the metabolic syndrome abnormalities and effect of Roux-en-Y gastric bypass in morbidly obese subjects

Authors :
Ary Serpa Neto
Felipe Martin Bianco Rossi
Rodrigo Dal Moro Amarante
Marçal Rossi
Source :
Einstein (São Paulo), Vol 9, Iss 4, Pp 429-435 (2011)
Publication Year :
2011
Publisher :
Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2011.

Abstract

ABSTRACT Objectives: To evaluate the relations between liver markers (GGT, ALT and AST) and the metabolic syndrome (and its components) in morbidly obese subjects, and to determine the response of these metabolic factors and hepatic enzymes after weight loss induced by Roux-en-Y gastric bypass. Methods: This study was carried out at a university hospital, in Santo André (SP), Brazil. We evaluated 140 morbidly obese subjects aged from 18 to 60 years submitted to a Roux-en-Y gastric bypass, who were followed for a mean period of 8 months. Patients with a history of heavy drinking, type 1 diabetes, and/or liver disease were excluded. Results: Liver markers, most notably GGT, were strongly associated with metabolic abnormalities, mainly hyperglycemia. The prevalence of type 2 diabetes significantly increased with increasing levels of GGT (highest versus lowest quartile GGT: odds ratio 3.89 [95%CI: 1.07-14.17]). Liver markers significantly decreased 8 months after the Roux-en-Y gastric bypass and the reduction of GGT levels were associated with the reduction of glucose levels (Pearson r = 0.286; p = 0.001). Conclusions: Elevated levels of liver markers, principally GGT, in morbidly obese subjects are associated with metabolic abnormalities. In addition to the well-known benefits of bariatric surgery, Roux-en-Y gastric bypass, reduced the levels of liver markers to the normal range.

Details

Language :
English, Portuguese
ISSN :
23176385 and 16794508
Volume :
9
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Einstein (São Paulo)
Publication Type :
Academic Journal
Accession number :
edsdoj.2894ddb6dd64ccd914bd0b0c4c1c89a
Document Type :
article
Full Text :
https://doi.org/10.1590/s1679-45082011ao2042