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Brain expression profiles of two SCN1A antisense RNAs in children and adolescents with epilepsy
- Source :
- Translational Neuroscience, Vol 15, Iss 1, Pp e1310-75 (2024)
- Publication Year :
- 2024
- Publisher :
- De Gruyter, 2024.
-
Abstract
- Heterozygous mutations within the voltage-gated sodium channel α subunit (SCN1A) are responsible for the majority of cases of Dravet syndrome (DS), a severe developmental and epileptic encephalopathy. Development of novel therapeutic approaches is mandatory in order to directly target the molecular consequences of the genetic defect. The aim of the present study was to investigate whether cis-acting long non-coding RNAs (lncRNAs) of SCN1A are expressed in brain specimens of children and adolescent with epilepsy as these molecules comprise possible targets for precision-based therapy approaches.
Details
- Language :
- English
- ISSN :
- 20816936 and 28947932
- Volume :
- 15
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Translational Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.28947932422c43fe927bd814144c42d9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/tnsci-2022-0330