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Stem cell sources for tooth regeneration: current status and future prospects

Authors :
Keishi eOtsu
Mika eKumakami-Sakano
Naoki eFujiwara
Kazuko eKikuchi
Laetitia eKeller
Hervé eLesot
Hidemitsu eHarada
Source :
Frontiers in Physiology, Vol 5 (2014)
Publication Year :
2014
Publisher :
Frontiers Media S.A., 2014.

Abstract

Stem cells are capable of renewing themselves through cell division and have the remarkable ability to differentiate into many different types of cells. They therefore have the potential to become a central tool in regenerative medicine. During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. Investigation of embryonic and adult (tissue) stem cells as potential cell sources for tooth regeneration has led to many promising results. However, technical and ethical issues have hindered the availability of these cells for clinical application. The recent discovery of induced pluripotent stem (iPS) cells has provided the possibility to revolutionize the field of regenerative medicine (dentistry) by offering the option of autologous transplantation. In this article, we review the current progress in the field of stem cell-based tooth regeneration and discuss the possibility of using iPS cells for this purpose.

Details

Language :
English
ISSN :
1664042X
Volume :
5
Database :
Directory of Open Access Journals
Journal :
Frontiers in Physiology
Publication Type :
Academic Journal
Accession number :
edsdoj.2840df19bc814350937b337e45172c8a
Document Type :
article
Full Text :
https://doi.org/10.3389/fphys.2014.00036