Back to Search
Start Over
Neonatal screening: 9% of children with filter paper thyroid‐stimulating hormone levels between 5 and 10 μIU/mL have congenital hypothyroidism
- Source :
- Jornal de Pediatria (Versão em Português), Vol 93, Iss 6, Pp 649-654 (2017)
- Publication Year :
- 2017
- Publisher :
- Brazilian Society of Pediatrics, 2017.
-
Abstract
- Objectives: To determine the prevalence of congenital hypothyroidism in children with filter paper TSH levels (f‐TSH) between 5 and 10 μUI/mL in the neonatal screening. Methods: This was a retrospective study including children screened from 2003 to 2010, with f‐TSH between 5 and 10 μIU/mL, who were followed‐up during the first two years of life when there was no serum TSH normalization. The diagnosis of congenital hypothyroidism was defined as serum TSH ≥10 μIU/mL and start of levothyroxine treatment up to 2 years of age. Results: Of the 380,741 live births, 3,713 (1.04%) had f‐TSH between 5 and 10 μIU /mL and, of these, 339 (9.13%) had congenital hypothyroidism. Of these, 76.11% of the cases were diagnosed in the first three months of life and 7.96% between 1 and 2 years of age. Conclusion: The study showed that 9.13% of the children with f‐TSH between 5 and 10 μIU/mL developed hypothyroidism and that in approximately one‐quarter of them, the diagnosis was confirmed only after the third month of life. Based on these findings, the authors suggest the use of a 5 μIU/mL cutoff for f‐TSH and long‐term follow‐up of infants whose serum TSH has not normalized to rule out congenital hypothyroidism.
Details
- Language :
- Portuguese
- ISSN :
- 22555536
- Volume :
- 93
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Jornal de Pediatria (Versão em Português)
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.283f97a9b1b2449f88de1a4d0f7ca4b9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jpedp.2017.08.001