Back to Search Start Over

Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

Authors :
Hussein A. Abbas
Dapeng Hao
Katarzyna Tomczak
Praveen Barrodia
Jin Seon Im
Patrick K. Reville
Zoe Alaniz
Wei Wang
Ruiping Wang
Feng Wang
Gheath Al-Atrash
Koichi Takahashi
Jing Ning
Maomao Ding
Hannah C. Beird
Jairo T. Mathews
Latasha Little
Jianhua Zhang
Sreyashi Basu
Marina Konopleva
Mario L. Marques-Piubelli
Luisa M. Solis
Edwin Roger Parra
Wei Lu
Auriole Tamegnon
Guillermo Garcia-Manero
Michael R. Green
Padmanee Sharma
James P. Allison
Steven M. Kornblau
Kunal Rai
Linghua Wang
Naval Daver
Andrew Futreal
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

The response rate of relapsed/refractory acute myeloid leukemia patients to PD-1 checkpoint blockade is low and unpredictable. Authors here show by single cell RNA sequencing, T cell receptor profiling and genomic analysis that the phenotypes and repertoire of CD8 + T cells and loss of chromosome 7/7q are important determinants of response.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.28224d44710d40fe8758d8643917f98e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26282-z