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A Concise Diastereoselective Total Synthesis of α-Ambrinol
- Source :
- Marine Drugs, Vol 21, Iss 4, p 230 (2023)
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- (−)-cis-α-Ambrinol is a natural product present in ambergris, a substance of marine origin that has been highly valued by perfumers. In this paper, we present a new approach to its total synthesis. The starting material is commercially available α-ionone and the key step is an intramolecular Barbier-type cyclization induced by CpTiCl2, an organometallic compound prepared in situ by a CpTiCl3 reduction with Mn.
- Subjects :
- ambergris
ambrinol
barbier reaction
CpTiCl2
Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 21040230 and 16603397
- Volume :
- 21
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Marine Drugs
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.27d2fe37306c4713a8996a6591575fd4
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/md21040230