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A defect in mitochondrial protein translation influences mitonuclear communication in the heart
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- The heart requires high levels of mitochondria to sustain function, and mitochondrial stressors can be transmitted to the nucleus and reprogram metabolism. Here, the authors show that a mitochondrial ribosomal protein is important for heart development in mice by increasing nuclear Klf15 expression.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.277c06198c448f2a5c8736ce2abe763
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-37291-5