Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas

Authors :: Matthew S. Dietz, DO
Catherine Z. Beach, BA
Ramon Barajas, MD
Michael S. Parappilly, BS
Sidharth K. Sengupta, BS
Lissa C. Baird, MD
Jeremy N. Ciporen, M
Seunggu J. Han, MD
Rebecca Loret de Mola, DO
Yoon Jae Cho, MD
Kellie J. Nazemi, MD
Shearwood McClelland, III, MD
Melissa H. Wong, PhD
Jerry J. Jaboin, MD, PhD
Source :: Advances in Radiation Oncology, Vol 5, Iss 2, Pp 152-162 (2020)
Publication Year :: 2020
Publisher :: Elsevier, 2020.
Abstract: Purpose: To review and critique the current state of liquid biopsy in pHGG. Materials and Methods: Published literature was reviewed for articles related to liquid biopsy in pediatric glioma and adult glioma with a focus on high-grade gliomas. Results: This review discusses the current state of liquid biomarkers of pHGG and their potential applications for liquid biopsy development. Conclusions: While nascent, the progress toward identifying circulating analytes of pHGG primes the field of neuro-oncoogy for liquid biopsy development.