Back to Search Start Over

Hormesis of Glyceollin I, an Induced Phytoalexin from Soybean, on Budding Yeast Chronological Lifespan Extension

Authors :
Yuancai Liu
Ziyun Wu
Shengbao Feng
Xuena Yang
Dejian Huang
Source :
Molecules, Vol 19, Iss 1, Pp 568-580 (2014)
Publication Year :
2014
Publisher :
MDPI AG, 2014.

Abstract

Glyceollin I, an induced phytoalexin isolated from soybean, has been reported to have various bioactivities, including anti-bacterial, anti-nematode, anti-fungal, anti-estrogenic and anti-cancer, anti-oxidant, anti-inflammatory, insulin sensitivity enhancing, and attenuation of vascular contractions. Here we show that glyceollin I has hormesis and extends yeast life span at low (nM) doses in a calorie restriction (CR)-dependent manner, while it reduces life span and inhibits yeast cell proliferation at higher (μM) doses. In contrast, the other two isomers (glyceollin II and III) cannot extend yeast life span and only show life span reduction and antiproliferation at higher doses. Our results in anti-aging activity indicate that glyceollin I might be a promising calorie restriction mimetic candidate, and the high content of glyceollins could improve the bioactivity of soybean as functional food ingredients.

Details

Language :
English
ISSN :
14203049
Volume :
19
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.2744c99a1b4cc9986079c787844d53
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules19010568