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Cartilage repair and inhibition of the progression of cartilage degeneration after transplantation of allogeneic chondrocyte sheets in a nontraumatic early arthritis model
- Source :
- Regenerative Therapy, Vol 9, Iss , Pp 24-31 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Introduction: Using a rat model of nontraumatic early arthritis induced by intra-articular administration of low-dose monoiodoacetic acid (MIA), we transplanted allogeneic chondrocyte sheets and examined the effects on tissue repair. Methods: MIA (0.2 mg/50 μl) was injected into the right knee of 20 male Wistar rats. Four weeks later, rats were randomly allocated into three groups: Group A was examined 4 weeks after administration of MIA; Group B, 8 weeks after MIA injection and chondrocyte sheet transplantation, and Group C, 8 weeks after MIA injection but without chondrocyte sheet transplantation. Allogeneic chondrocyte sheets were transplanted into the right knee of Group B rats. Pain was assessed as the weight distribution ratio of the damaged to undamaged limb. The OARSI score was used for histological scoring. Results: The limb weight distribution ratio indicated significantly less pain in Group B. Histological scoring showed significant differences in cartilage repair and inhibition of the progression of cartilage degeneration between Groups B and C, but not between Groups A and B, or Groups A and C. Conclusions: These findings suggest that, in this rat model of nontraumatic early arthritis induced by low-dose MIA injection, allogeneic chondrocyte sheet transplantation induces cartilage repair and suppresses cartilage degeneration. Keywords: Osteoarthritis, Chondrocyte sheet, Transplantation, Monoiodoacetic acid (MIA), OARSI score
- Subjects :
- Medicine (General)
R5-920
Cytology
QH573-671
Subjects
Details
- Language :
- English
- ISSN :
- 23523204
- Volume :
- 9
- Issue :
- 24-31
- Database :
- Directory of Open Access Journals
- Journal :
- Regenerative Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.26e6aa6924346d986e0129e89edd97d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.reth.2018.07.003