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Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
- Source :
- Química Nova, Vol 28, Iss 1, Pp 54-56 (2005)
- Publication Year :
- 2005
- Publisher :
- Sociedade Brasileira de Química, 2005.
-
Abstract
- A simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric method for sulfate ion quantitation using 0.1 mol L-1 lead perchlorate as titrant. Both methods were validated concerning linearity, precision and accuracy, yielding good results. The sulfate ion content found by the two validated methods was compared by the statistical t-student test, indicating that there was no statistically significant difference between the methods.
- Subjects :
- indinavir sulfate
titration
sulfate ion content
Chemistry
QD1-999
Subjects
Details
- Language :
- English, Spanish; Castilian, Portuguese
- ISSN :
- 01004042 and 16787064
- Volume :
- 28
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Química Nova
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.26e04e8561b64db5bcc4de347a36cfa8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/S0100-40422005000100011