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Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist

Authors :
Giulia Parisi
Justin D. Saco
Felix B. Salazar
Jennifer Tsoi
Paige Krystofinski
Cristina Puig-Saus
Ruixue Zhang
Jing Zhou
Gardenia C. Cheung-Lau
Alejandro J. Garcia
Catherine S. Grasso
Richard Tavaré
Siwen Hu-Lieskovan
Sean Mackay
Jonathan Zalevsky
Chantale Bernatchez
Adi Diab
Anna M. Wu
Begoña Comin-Anduix
Deborah Charych
Antoni Ribas
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Adoptive cell transfer (ACT) of T cells for tumor treatment often requires IL-2 administration. Here, the authors show that a modified IL-2 cytokine (NKTR-214) can outperform IL-2 in a melanoma mouse model.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.26da1a14c88d4cdbbb1ebbe52eeb9731
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12901-3