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How can heatstroke damage the brain? A mini review

Authors :
Kazuhiro Yoneda
Sanae Hosomi
Hiroshi Ito
Yuki Togami
Sayaka Oda
Hisatake Matsumoto
Junya Shimazaki
Hiroshi Ogura
Jun Oda
Source :
Frontiers in Neuroscience, Vol 18 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Record-breaking heat waves over the past 20 years have led to a global increase in heat-related deaths, including heatstroke. Heat-related illnesses occur when the body cannot adapt to the elevated temperatures in the environment, leading to various symptoms. In severe situations, such as heatstroke, the body temperature can rise above 40°C, leading to significant injury to body systems, with particular susceptibility of the central nervous system (CNS). Neuroimaging studies conducted months or years after a heatstroke have revealed cellular damage in the cerebellum and other brain regions, including the hippocampus, midbrain, and thalamus, with the potential for long-term neurological complications in survivors of a heatstroke. This mini review aimed to describe the mechanisms and pathways underlying the development of brain injury induced by heatstroke and identify diagnostic imaging tools and biomarkers for injury to the CNS due to a heatstroke.

Details

Language :
English
ISSN :
1662453X
Volume :
18
Database :
Directory of Open Access Journals
Journal :
Frontiers in Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.26b1a9d42f1c43aa98d12237aaff440a
Document Type :
article
Full Text :
https://doi.org/10.3389/fnins.2024.1437216