Back to Search
Start Over
Effects of fluoridation of porcine hydroxyapatite on osteoblastic activity of human MG63 cells
- Source :
- Science and Technology of Advanced Materials, Vol 16, Iss 3 (2015)
- Publication Year :
- 2015
- Publisher :
- Taylor & Francis Group, 2015.
-
Abstract
- Biological hydroxyapatite, derived from animal bones, is the most widely used bone substitute in orthopedic and dental treatments. Fluorine is the trace element involved in bone remodeling and has been confirmed to promote osteogenesis when administered at the appropriate dose. To take advantage of this knowledge, fluorinated porcine hydroxyapatite (FPHA) incorporating increasing levels of fluoride was derived from cancellous porcine bone through straightforward chemical and thermal treatments. Physiochemical characteristics, including crystalline phases, functional groups and dissolution behavior, were investigated on this novel FPHA. Human osteoblast-like MG63 cells were cultured on the FPHA to examine cell attachment, cytoskeleton, proliferation and osteoblastic differentiation for in vitro cellular evaluation. Results suggest that fluoride ions released from the FPHA play a significant role in stimulating osteoblastic activity in vitro, and appropriate level of fluoridation (1.5 to 3.1 atomic percents of fluorine) for the FPHA could be selected with high potential for use as a bone substitute.
Details
- Language :
- English
- ISSN :
- 14686996 and 18785514
- Volume :
- 16
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Science and Technology of Advanced Materials
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.26aa35bb7f8f42679b7170358b7ad378
- Document Type :
- article
- Full Text :
- https://doi.org/10.1088/1468-6996/16/3/035006