Back to Search
Start Over
The relationship between blood pressure and cognitive function
- Source :
- International Journal of Cardiology. Cardiovascular Risk and Prevention, Vol 10, Iss , Pp 200104- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Background: Although an elevated systolic blood pressure (SBP) is associated with cognitive dysfunction, BP may decrease with advanced cognitive dysfunction; therefore, we attempted to identify the turning point in the relationship between cognitive function and SBP in elderly subjects. Methods: In pooled datasets of general populations and outpatient clinics (age>65 years), in which the risk of frailty or cognitive dysfunction was assessed (N = 4076), the relationship between SBP and the Mini Mental State Examination (MMSE) score was examined. Results: Mean age was 72.5 ± 6.2 years (male 45.1%), and SBP was 133.0 ± 19.5 mmHg. In an analysis of locally weighted scatter plot smoothing, the relationship between SBP and MMSE scores changed at an MMSE score of 24 points. In subjects with preserved cognitive function (MMSE ≥24 points), MMSE scores decreased with increases in SBP (B = −0.047 per 10 mmHg increase, P = 0.002) after adjustments for age, sex, body mass index, alcohol habit, smoking status, diabetes, a history of stroke, and the geriatric nutritional index; however, in subjects with reduced cognitive function (MMSE
Details
- Language :
- English
- ISSN :
- 27724875
- Volume :
- 10
- Issue :
- 200104-
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Cardiology. Cardiovascular Risk and Prevention
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.264dd705ac0b43d08a2a3c325c90c789
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ijcrp.2021.200104