Preparation of Prodrug from Indomethacine and Ascorbic acid and study of It's Effect on Asparatate amino transferase Enzyme Partially Purified from Blood of Diabetic Patients Type two.

The aim of this study is to prepare a new ester prodrug. used for this purpose ascorbic acid vitamin C and indomethacin by esterification reaction, and partial purification of the AST from blood serum with diabetes type II, and we following steps: 1-preparation of indomethacin chloride by reaction of indomethacin with thionyl chloride.esterification reaction of the hydroxy group in vitamin C with Indomethacin chloride to produce ester indomethacin. And Identification of Structural formula using spectroscopic methods (FTIR(. 2-measuring the AST activity in the blood serum of people with diabetes and blood serum of healthy people. The study included 35 patients serum sample for Type II diabetes and (25) of the serum sample healthy. The control group was observed high level of probability (p