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Vitamin D Prevents High Glucose-Induced Lipid Droplets Accumulation in Cultured Endothelial Cells: The Role of Thioredoxin Interacting Protein

Authors :
Roberta Scrimieri
Alessandra Cazzaniga
Sara Castiglioni
Jeanette A. M. Maier
Source :
Biomedicines, Vol 9, Iss 12, p 1874 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Vitamin D (VitD) exerts protective effects on the endothelium, which is fundamental for vascular integrity, partly by inhibiting free radical formation. We found that VitD prevents high glucose-induced Thioredoxin Interacting Protein (TXNIP) upregulation. Increased amounts of TXNIP are responsible for the accumulation of reactive oxygen species and, as a consequence, of lipid droplets. This is associated with increased amounts of triglycerides as the result of increased lipogenesis and reduced fatty acid oxidation. Remarkably, VitD rebalances the redox equilibrium, restores normal lipid content, and prevents the accumulation of lipid droplets. Our results highlight TXNIP as one of the targets of VitD in high glucose-cultured endothelial cells and shed some light on the protective effect of VitD on the endothelium.

Details

Language :
English
ISSN :
22279059
Volume :
9
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.2610a66b5d8742fba22e03e3c70a647d
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines9121874