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The Development and Pre-Clinical Anti-Inflammatory Efficacy of a New Transdermal Ureasil–Polyether Hybrid Matrix Loaded with Flavonoid-Rich Annona muricata Leaf Extract

Authors :
Camila Beatriz Barros Araújo
José de Oliveira Alves Júnior
Mariana Rillo Sato
Kammila Martins Nicolau Costa
Jéssica Roberta Lima
Bolívar Ponciano Goulart de Lima Damasceno
Francisco José Batista de Lima Junior
Bruna Galdorfini Chiari Andréo
Vanda Lucia dos Santos
João Augusto Oshiro-Junior
Source :
Pharmaceutics, Vol 16, Iss 8, p 1097 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

This study aimed to develop a novel ureasil–polyether transdermal hybrid matrix (U-PEO) loaded with Annona muricata concentrated extract (AMCE), which exhibits potent anti-inflammatory activity. The extract was obtained by maceration, a method that allowed for the extraction of a high concentration of flavonoids (39.27 mg/g of extract). In vivo tests demonstrated that 10 mg/kg of AMCE inhibited inflammation for 6 h. The physicochemical characterization of U-PEO with AMCE was conducted via a thermogravimetric analysis (TGA), while its surface was recorded using atomic force microscopy (AFM). The in vitro macroscopic swelling and release tests demonstrated the hydrophilic profile of the material and the percentage of AMCE released. The TGA results demonstrated that the system exhibited physical compatibility due to the thermal stability of U-PEO. Additionally, the AFM analysis revealed a rough and porous surface, with a particular emphasis on the system with AMCE. The release resulted in the liberation of 23.72% of AMCE within 24 h. Finally, the preclinical tests demonstrated that U-PEO with AMCE was also capable of effectively inhibiting inflammation for 6 h, a duration comparable to that of a commercial formulation. The results permit the advancement of the study towards the development of a transdermal system, thereby rendering its application in clinical studies feasible.

Details

Language :
English
ISSN :
19994923
Volume :
16
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.25e764aa639045eebe7ebba02002015e
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics16081097