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Assessment of local and systemic inflammatory parameters of peripheral burn in an animal model
- Source :
- Revista Peruana de Medicina Experimental y Salud Pública, Vol 33, Iss 4, Pp 713-718 (2016)
- Publication Year :
- 2016
- Publisher :
- Instituto Nacional de Salud, 2016.
-
Abstract
- To evaluate the edema volume and leukocyte, platelet, and fibrinogen count of peripheral burn in an animal model. The back left leg of Rattus norvegicus (experimental group) was placed in water at 60 °C for 60 seconds or at room temperature (control group). An analysis was carried out before and after the induced burn (at 4, 8, 12, and 24 h). The edema volume was determined by an orthogonal photo, the leukocyte and platelet counts were determined using automated equipment, and the fibrinogen count was determined using the gravimetric method. The maximum value of the edema was recorded at 4 h and leukocytes at 24 h. The platelet count did not vary at different post-edema time intervals. The fibrinogen level increased at 4 h and 24 h. In this animal model we induced systemic inflammation characterized by leukocytosis and elevated fibrinogen levels, combined with edema located at the induction area.
- Subjects :
- quemadura
edema
leucocitos
plaquetas
fibrinógeno
Medicine
Medicine (General)
R5-920
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 17264634 and 17264642
- Volume :
- 33
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Revista Peruana de Medicina Experimental y Salud Pública
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.25c245c0fe34171a963fab213199d1b
- Document Type :
- article
- Full Text :
- https://doi.org/10.17843/rpmesp.2016.334.2556