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Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis

Authors :
Snaevar Sigurdsson
Kristjan F. Alexandersson
Patrick Sulem
Bjarke Feenstra
Steinunn Gudmundsdottir
Gisli H. Halldorsson
Sigurgeir Olafsson
Asgeir Sigurdsson
Thorunn Rafnar
Thorgeir Thorgeirsson
Erik Sørensen
Andreas Nordholm-Carstensen
Jakob Burcharth
Jens Andersen
Henrik Stig Jørgensen
Emma Possfelt-Møller
Henrik Ullum
Gudmar Thorleifsson
Gisli Masson
Unnur Thorsteinsdottir
Mads Melbye
Daniel F. Gudbjartsson
Tryggvi Stefansson
Ingileif Jonsdottir
Kari Stefansson
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

A hallmark of diverticular disease is pouches in the bowel wall which can become infected and inflamed, causing the more severe diverticulitis. Here, the authors report the first genome-wide association study on these interconnected conditions and identifyARHGAP15, COLQ and FAM155Aas novel risk loci.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.258e8dbdaa804b238425c04454008702
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms15789