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Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology.

Authors :
Bernhard Moser
Stefan Janik
Ana-Iris Schiefer
Leonhard Müllauer
Christine Bekos
Anke Scharrer
Michael Mildner
Ferenc Rényi-Vámos
Walter Klepetko
Hendrik Jan Ankersmit
Source :
PLoS ONE, Vol 9, Iss 4, p e94118 (2014)
Publication Year :
2014
Publisher :
Public Library of Science (PLoS), 2014.

Abstract

Recently, a role of the receptor for advanced glycation endproducts (RAGE) in myasthenia gravis was described. RAGE and its ligand high mobility group box 1 (HMGB1) play key roles in autoimmunity and cancer. To test whether these molecules are involved in patients with thymic abnormalities we applied immunohistochemical analysis in 33 cases of thymic epithelial tumors, comprising 27 thymomas and 6 thymic carcinomas, and 21 nonneoplastic thymuses. Both molecules were detected in neoplastic epithelial cells: RAGE staining was most intense in WHO type B2 thymomas and thymic carcinomas (pB3>thymic carcinoma (p

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
9
Issue :
4
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.255f8f9d69364cacb3270207118393d9
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0094118