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Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma

Authors :
Shannon Coy
Shu Wang
Sylwia A. Stopka
Jia-Ren Lin
Clarence Yapp
Cecily C. Ritch
Lisa Salhi
Gregory J. Baker
Rumana Rashid
Gerard Baquer
Michael Regan
Prasidda Khadka
Kristina A. Cole
Jaeho Hwang
Patrick Y. Wen
Pratiti Bandopadhayay
Mariarita Santi
Thomas De Raedt
Keith L. Ligon
Nathalie Y. R. Agar
Peter K. Sorger
Mehdi Touat
Sandro Santagata
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The components of the glioma immune microenvironment and their roles in promoting tumourigenesis remain poorly understood. Here, the use of single-cell RNA sequencing and multiplexed tissue-imaging in adult and pediatric high-grade gliomas reveals the activity and spatial organization of the immunomodulatory purinergic signaling pathway.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.253b0fa0fb184487ac96b60cc93df6f3
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-32430-w