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Metabolomic markers of glucose regulation after a lifestyle intervention in prediabetes
- Source :
- BMJ Open Diabetes Research & Care, Vol 10, Iss 5 (2022)
- Publication Year :
- 2022
- Publisher :
- BMJ Publishing Group, 2022.
-
Abstract
- Introduction Disentangling the specific factors that regulate glycemia from prediabetes to normoglycemia could improve type 2 diabetes prevention strategies. Metabolomics provides substantial insights into the biological understanding of environmental factors such as diet. This study aimed to identify metabolomic markers of regression to normoglycemia in the context of a lifestyle intervention (LSI) in individuals with prediabetes.Research design and methods We conducted a single-arm intervention study with 24 weeks of follow-up. Eligible study participants had at least one prediabetes criteria according to the American Diabetes Association guidelines, and body mass index between 25 and 45 kg/m2. LSI refers to a hypocaloric diet and >150 min of physical activity per week. Regression to normoglycemia (RNGR) was defined as achieving hemoglobin A1c (HbA1c)
- Subjects :
- Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Subjects
Details
- Language :
- English
- ISSN :
- 20220030 and 20524897
- Volume :
- 10
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- BMJ Open Diabetes Research & Care
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.25356bd47d04aff8239ba95a6c7c0bc
- Document Type :
- article
- Full Text :
- https://doi.org/10.1136/bmjdrc-2022-003010