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DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample
- Source :
- Epigenetics, Vol 16, Iss 11, Pp 1169-1186 (2021)
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis Group, 2021.
-
Abstract
- Accumulating evidence suggests that individuals exposed to victimization at key developmental stages may have different epigenetic fingerprints compared to those exposed to no/minimal stressful events, however results are inconclusive. This study aimed to strengthen causal inference regarding the impact of adolescent victimization on the epigenome by controlling for genetic variation, age, gender, and shared environmental exposures. We conducted longitudinal epigenome-wide association analyses (EWAS) on DNA methylation (DNAm) profiles of 118 monozygotic (MZ) twin pairs from the Environmental Risk study with and without severe adolescent victimization generated using buccal DNA collected at ages 5, 10 and 18, and the Illumina EPIC array. Additionally, we performed cross-sectional EWAS on age-18 blood and buccal DNA from the same individuals to elucidate tissue-specific signatures of severe adolescent victimization. Our analyses identified 20 suggestive differentially methylated positions (DMPs) (P
Details
- Language :
- English
- ISSN :
- 15592294 and 15592308
- Volume :
- 16
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Epigenetics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.24e922fd7bc4d3991b7688caaddd685
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/15592294.2020.1853317