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Pharmacokinetic Modeling of VV116 for Treatment of COVID-19
- Source :
- BIO Web of Conferences, Vol 60, p 02007 (2023)
- Publication Year :
- 2023
- Publisher :
- EDP Sciences, 2023.
-
Abstract
- SARS-Cov-2 is still impacting global health and potentially will live with human in the near future. Therefore, effective oral medicines such as VV116 will play an important role in treating numerous patients and ending the pandemic. From this research, these simulated results can be used to guide clinical decisions to maximize therapeutic benefits of VV116 while avoiding potential toxicities. This compartmental modeling approach can be readily used for other drugs that have identical physiochemical properties in the clinical trial. However, caution should be exercised when the dose exceeds the linear PK range (up to 1200 mg in this case), where the model becomes invalid. As such, future study is needed to examine mixed-order or zero order PK where the dose-response is not linear. The importance of biomedical research has also inspired me to pursue a future career to fighting diseases with unmet medical needs.
- Subjects :
- Microbiology
QR1-502
Physiology
QP1-981
Zoology
QL1-991
Subjects
Details
- Language :
- English, French
- ISSN :
- 21174458
- Volume :
- 60
- Database :
- Directory of Open Access Journals
- Journal :
- BIO Web of Conferences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.24e63276859747ce8ec4496702bbc159
- Document Type :
- article
- Full Text :
- https://doi.org/10.1051/bioconf/20236002007