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Loss of Female Sex Hormones Exacerbates Cerebrovascular and Cognitive Dysfunction in Aortic Banded Miniswine Through a Neuropeptide Y–Ca2+‐Activated Potassium Channel–Nitric Oxide Mediated Mechanism

Authors :
T. Dylan Olver
Jessica A. Hiemstra
Jenna C. Edwards
Todd R. Schachtman
Cheryl M. Heesch
Paul J. Fadel
M. Harold Laughlin
Craig A. Emter
Source :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 11 (2017)
Publication Year :
2017
Publisher :
Wiley, 2017.

Abstract

BackgroundPostmenopausal women represent the largest cohort of patients with heart failure with preserved ejection fraction, and vascular dementia represents the most common form of dementia in patients with heart failure with preserved ejection fraction. Therefore, we tested the hypotheses that the combination of cardiac pressure overload (aortic banding [AB]) and the loss of female sex hormones (ovariectomy [OVX]) impairs cerebrovascular control and spatial memory. Methods and ResultsFemale Yucatan miniswine were separated into 4 groups (n=7 per group): (1) control, (2) AB, (3) OVX, and (4) AB‐OVX. Pigs underwent OVX and AB at 7 and 8 months of age, respectively. At 14 months, cerebral blood flow velocity and spatial memory (spatial hole‐board task) were lower in the OVX groups (P

Details

Language :
English
ISSN :
20479980
Volume :
6
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.24df2e1448ec451aa6136ec095e209fd
Document Type :
article
Full Text :
https://doi.org/10.1161/JAHA.117.007409