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Intracellular Host Restriction of Hepatitis B Virus Replication

Authors :
Prakriti Sinha
Chloe L. Thio
Ashwin Balagopal
Source :
Viruses, Vol 16, Iss 5, p 764 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The hepatitis B virus (HBV) infects hepatocytes and hijacks host cellular mechanisms for its replication. Host proteins can be frontline effectors of the cell’s defense and restrict viral replication by impeding multiple steps during its intracellular lifecycle. This review summarizes many of the well-described restriction factors, their mechanisms of restriction, and counteractive measures of HBV, with a special focus on viral transcription. We discuss some of the limitations and knowledge gaps about the restriction factors, highlighting how these factors may be harnessed to facilitate therapeutic strategies against HBV.

Details

Language :
English
ISSN :
19994915
Volume :
16
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.249a04dd8e184ee8acb66971ab7e0917
Document Type :
article
Full Text :
https://doi.org/10.3390/v16050764