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Type 2 diabetes complications and comorbidity in Sub-Saharan Africans

Type 2 diabetes complications and comorbidity in Sub-Saharan Africans

Authors :
Kenneth Ekoru
Ayo Doumatey
Amy R. Bentley
Guanjie Chen
Jie Zhou
Daniel Shriner
Olufemi Fasanmade
Godfrey Okafor
Benjamin Eghan, Jr
Kofi Agyenim-Boateng
Jokotade Adeleye
Williams Balogun
Albert Amoah
Joseph Acheampong
Thomas Johnson
Johnnie Oli
Clement Adebamowo
Francis Collins
Georgia Dunston
Adebowale Adeyemo
Charles Rotimi
Source :
EClinicalMedicine, Vol 16, Iss , Pp 30-41 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Background: Context-specific evidence of the spectrum of type 2 diabetes (T2D) burden is essential for setting priorities and designing interventions to reduce associated morbidity and mortality. However, there are currently limited data on the burden of T2D complications and comorbidity in sub-Saharan Africa (SSA). Methods: T2D complications and comorbidities were assessed in 2,784 participants with diabetes enrolled from tertiary health centres and contextualised in 3,209 individuals without diabetes in Nigeria, Ghana and Kenya. T2D complications and comorbidities evaluated included cardiometabolic, ocular, neurological and renal characteristics. Findings: The most common complications/comorbidities among the T2D participants were hypertension (71%; 95% CI 69–73), hyperlipidaemia (34%; 95% CI 32–36), and obesity (27%; 95% CI 25–29). Additionally, the prevalence of cataracts was 32% (95% CI 30–35), diabetic retinopathy 15% (95% CI 13–17), impaired renal function 13% (95% CI 12–15), and erectile dysfunction (in men) 35% (95% CI 32–38). T2D population-attributable fraction for these comorbidities ranged between 6 and 64%. Interpretation: The burden of diabetes complications and comorbidity is substantial in SSA highlighting the urgent need for innovative public health strategies that prioritise promotion of healthy lifestyles for prevention and early detection of T2D. Also needed are strategies to strengthen health care system capacities to provide treatment and care for diabetes complications. Keywords: Type 2 Diabetes, Sub-Sahara Africa, Complications, Co-morbidity, Epidemiology

Subjects

Subjects :
Medicine (General)
R5-920

Details

Language :
English
ISSN :
25895370
Volume :
16
Issue :
30-41
Database :
Directory of Open Access Journals
Journal :
EClinicalMedicine
Publication Type :
Academic Journal
Accession number :
edsdoj.248abf1d31a142e4b6e92dbaaa13d52d
Document Type :
article
Full Text :
https://doi.org/10.1016/j.eclinm.2019.09.001