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The Gut Microbiome of Children during the COVID-19 Pandemic

The Gut Microbiome of Children during the COVID-19 Pandemic

Authors :
Mickayla Bacorn
Hector N. Romero-Soto
Shira Levy
Qing Chen
Suchitra K. Hourigan
Source :
Microorganisms, Vol 10, Iss 12, p 2460 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The gut microbiome has been shown to play a critical role in maintaining a healthy state. Dysbiosis of the gut microbiome is involved in modulating disease severity and potentially contributes to long-term outcomes in adults with COVID-19. Due to children having a significantly lower risk of severe illness and limited sample availability, much less is known about the role of the gut microbiome in children with COVID-19. It is well recognized that the developing gut microbiome of children differs from that of adults, but it is unclear if this difference contributes to the different clinical presentations and complications. In this review, we discuss the current knowledge of the gut microbiome in children with COVID-19, with gut microbiome dysbiosis being found in pediatric COVID-19 but specific taxa change often differing from those described in adults. Additionally, we discuss possible mechanisms of how the gut microbiome may mediate the presentation and complications of COVID-19 in children and the potential role for microbial therapeutics.

Details

Language :
English
ISSN :
20762607
Volume :
10
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
edsdoj.24435c6dd91a402eaceffd7e0e374db9
Document Type :
article
Full Text :
https://doi.org/10.3390/microorganisms10122460