Back to Search Start Over

Widespread subclinical cellular changes revealed across a neural-epithelial-vascular complex in choroideremia using adaptive optics

Authors :
Nancy Aguilera
Tao Liu
Andrew J. Bower
Joanne Li
Sarah Abouassali
Rongwen Lu
John Giannini
Maximilian Pfau
Chelsea Bender
Margery G. Smelkinson
Amelia Naik
Bin Guan
Owen Schwartz
Andrei Volkov
Alfredo Dubra
Zhuolin Liu
Daniel X. Hammer
Dragan Maric
Robert Fariss
Robert B. Hufnagel
Brett G. Jeffrey
Brian P. Brooks
Wadih M. Zein
Laryssa A. Huryn
Johnny Tam
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The in vivo pathogenesis of the blinding retinal degeneration choroideremia is visualized, which reveals enlarged and area-disrupted retinal pigment epithelial cells, providing evidence for polymegathism in choroideremia.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.23f1aa92e6bc467cb2c2e52b88e2d152
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03842-7