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Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia
- Source :
- Case Reports in Hematology, Vol 2018 (2018)
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Updated WHO criteria define mixed phenotype acute leukemia (MPAL) with more stringent diagnostic criteria than the formerly described entity biphenotypic acute leukemia (BAL). The changes in diagnostic criteria influence management by assigning weight to aberrantly expressed markers and minimizing expression of myeloid markers other than myeloperoxidase (MPO), potentially foregoing consolidative allogeneic transplant for an otherwise “favorable” lymphoid phenotypic leukemia. We present a case of MPO-negative, myeloid antigen-positive acute lymphoblastic leukemia who progressed with refractory phenotypic acute myeloid leukemia while receiving lymphoid-directed therapy and discuss concerns raised by the adoption of the new, more stringent diagnostic criteria for BAL.
- Subjects :
- Diseases of the blood and blood-forming organs
RC633-647.5
Subjects
Details
- Language :
- English
- ISSN :
- 20906560 and 20906579
- Volume :
- 2018
- Database :
- Directory of Open Access Journals
- Journal :
- Case Reports in Hematology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.23995debc8a248129a8fcd32a98a821d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2018/7456378