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H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors

Authors :
Shaofei Zhang
Yuri Postnikov
Alexei Lobanov
Takashi Furusawa
Tao Deng
Michael Bustin
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The nucleosome-binding proteins HMGN1 and HMGN2 prefer acetylated nucleosomes at H3K27ac and the loss of this interaction alters binding of transcription factors to chromatin.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.238a02973f426a873b928e07a51622
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03099-0