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Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women.

Authors :
Pilar Requena
Edmilson Rui
Norma Padilla
Flor E Martínez-Espinosa
Maria Eugenia Castellanos
Camila Bôtto-Menezes
Adriana Malheiro
Myriam Arévalo-Herrera
Swati Kochar
Sanjay K Kochar
Dhanpat K Kochar
Alexandra J Umbers
Maria Ome-Kaius
Regina Wangnapi
Dhiraj Hans
Michela Menegon
Francesca Mateo
Sergi Sanz
Meghna Desai
Alfredo Mayor
Chetan C Chitnis
Azucena Bardají
Ivo Mueller
Stephen Rogerson
Carlo Severini
Carmen Fernández-Becerra
Clara Menéndez
Hernando Del Portillo
Carlota Dobaño
Source :
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005009 (2016)
Publication Year :
2016
Publisher :
Public Library of Science (PLoS), 2016.

Abstract

P. vivax infection during pregnancy has been associated with poor outcomes such as anemia, low birth weight and congenital malaria, thus representing an important global health problem. However, no vaccine is currently available for its prevention. Vir genes were the first putative virulent factors associated with P. vivax infections, yet very few studies have examined their potential role as targets of immunity. We investigated the immunogenic properties of five VIR proteins and two long synthetic peptides containing conserved VIR sequences (PvLP1 and PvLP2) in the context of the PregVax cohort study including women from five malaria endemic countries: Brazil, Colombia, Guatemala, India and Papua New Guinea (PNG) at different timepoints during and after pregnancy. Antibody responses against all antigens were detected in all populations, with PNG women presenting the highest levels overall. P. vivax infection at sample collection time was positively associated with antibody levels against PvLP1 (fold-increase: 1.60 at recruitment -first antenatal visit-) and PvLP2 (fold-increase: 1.63 at delivery), and P. falciparum co-infection was found to increase those responses (for PvLP1 at recruitment, fold-increase: 2.25). Levels of IgG against two VIR proteins at delivery were associated with higher birth weight (27 g increase per duplicating antibody levels, p

Details

Language :
English
ISSN :
19352727 and 19352735
Volume :
10
Issue :
10
Database :
Directory of Open Access Journals
Journal :
PLoS Neglected Tropical Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.23771e6cc1c4f6b99db16961d07ba13
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pntd.0005009