Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis.

Authors :: Tara C Bouton
Margaretha de Vos
Elizabeth J Ragan
Laura F White
Leonie Van Zyl
Danie Theron
C Robert Horsburgh
Robin M Warren
Karen R Jacobson
Source :: PLoS ONE, Vol 14, Iss 10, p e0223308 (2019)
Publication Year :: 2019
Publisher :: Public Library of Science (PLoS), 2019.
Abstract: South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance.

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