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The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats

The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats

Authors :
Jung Hee Lee
Yun Kyu Lee
Hyun-Jong Lee
Jae Soo Kim
Source :
Journal of Acupuncture Research, Vol 38, Iss 2, Pp 140-145 (2021)
Publication Year :
2021
Publisher :
MEDrang Inc., 2021.

Abstract

Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain.

Details

Language :
English, Korean
ISSN :
2586288X and 25862898
Volume :
38
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Journal of Acupuncture Research
Publication Type :
Academic Journal
Accession number :
edsdoj.2327dd01e963418087e03eb63ff6e135
Document Type :
article
Full Text :
https://doi.org/10.13045/jar.2020.00409