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The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats
The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats
- Source :
- Journal of Acupuncture Research, Vol 38, Iss 2, Pp 140-145 (2021)
- Publication Year :
- 2021
- Publisher :
- MEDrang Inc., 2021.
-
Abstract
- Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain.
Details
- Language :
- English, Korean
- ISSN :
- 2586288X and 25862898
- Volume :
- 38
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Acupuncture Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2327dd01e963418087e03eb63ff6e135
- Document Type :
- article
- Full Text :
- https://doi.org/10.13045/jar.2020.00409