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mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential for endplate maintenance upon nerve injury
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2327d58d6a49b7a54e496210a1a5f2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-11227-4