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Composite Polysaccharide Hydrogel Loaded with Scutellaria baicalensis Extract for Diabetic Wound Treatment

Authors :
Yumeng Zhu
Fangyan Li
Shuo Wang
Hongmei Shi
Minqian Zhao
Shaohong You
Sibo Su
Gang Cheng
Source :
Gels, Vol 10, Iss 9, p 605 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Diabetic wounds present significant burdens to both patients and the healthcare system due to their prolonged inflammatory phase and adverse microenvironment. Traditional Chinese medicine (TCM), particularly Scutellaria baicalensis extract (SE), has shown promise in wound healing. Herein, sesbania gum (SG) was oxidized and formed hydrogel with carboxymethyl chitosan (CMCS) through the imine bond. Then, SE was loaded into the hydrogel as a wound dressing (CMCS−OSG@SE hydrogel). In vitro experiments demonstrated the mechanical properties and ROS scavenging efficiency of the hydrogel, as well as the release of SE and its biocompatibility. In an vivo study, diabetic mice with S. aureus infection were used, and the CMCS−-OSG@SE hydrogel dressing accelerated wound healing by promoting epidermal regeneration and collagen deposition. This composite polysaccharide hydrogel loaded with SE shows great potential for diabetic wound treatment.

Details

Language :
English
ISSN :
23102861
Volume :
10
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Gels
Publication Type :
Academic Journal
Accession number :
edsdoj.23173b0184024345a33a94a3f8305453
Document Type :
article
Full Text :
https://doi.org/10.3390/gels10090605