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Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis

Authors :
Sean P. Pitroda
Nikolai N. Khodarev
Lei Huang
Abhineet Uppal
Sean C. Wightman
Sabha Ganai
Nora Joseph
Jason Pitt
Miguel Brown
Martin Forde
Kathy Mangold
Lai Xue
Christopher Weber
Jeremy P. Segal
Sabah Kadri
Melinda E. Stack
Sajid Khan
Philip Paty
Karen Kaul
Jorge Andrade
Kevin P. White
Mark Talamonti
Mitchell C. Posner
Samuel Hellman
Ralph R. Weichselbaum
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

The oligometastasis hypothesis suggests certain metastases are limited in extent and curable with focal therapies. Here they identify three integrated molecular subtypes of colorectal cancer liver metastasis, which complement clinical risk stratification to distinguish the subset of oligometastatic patients.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.22f79936b0e641648e56509a01ce8a84
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-04278-6