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Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential

Authors :
Lizdany Flórez-Álvarez
Edmarcia Elisa de Souza
Viviane Fongaro Botosso
Danielle Bruna Leal de Oliveira
Paulo Lee Ho
Carlos Pelleschi Taborda
Giuseppe Palmisano
Margareth Lara Capurro
João Renato Rebello Pinho
Helena Lage Ferreira
Paola Minoprio
Eurico Arruda
Luís Carlos de Souza Ferreira
Carsten Wrenger
Edison Luiz Durigon
Source :
Frontiers in Microbiology, Vol 13 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored. In this minireview, we address the current knowledge of the mechanisms underlying VHFs pathogenesis and discuss the available development of preventive and therapeutic options to treat these infections. Furthermore, we discuss the potential of HFVs to cause worldwide emergencies along with factors that favor their spread beyond their original niches.

Details

Language :
English
ISSN :
1664302X
Volume :
13
Database :
Directory of Open Access Journals
Journal :
Frontiers in Microbiology
Publication Type :
Academic Journal
Accession number :
edsdoj.22e4f97efec644c296da8bf0aae66662
Document Type :
article
Full Text :
https://doi.org/10.3389/fmicb.2022.1040093