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Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

Authors :
David A. Ruhl
Ewa Bomba-Warczak
Emma T. Watson
Mazdak M. Bradberry
Tabitha A. Peterson
Trina Basu
Alyssa Frelka
Chantell S. Evans
Joseph S. Briguglio
Tamara Basta
Michael H. B. Stowell
Jeffrey N. Savas
Avtar Roopra
Robert A. Pearce
Robert C. Piper
Edwin R. Chapman
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independent functions: controlling neurite outgrowth and synaptic physiology

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2285b841eadf401cae3e662ea7ba2f42
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11459-4